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Harringtonine
🥰Excellent
Catalog No. T8286Cas No. 26833-85-2
Harringtonine is a naturally occurring alkaloid that inhibits DNA synthesis and protein synthesis and strongly kills S-phase cells. Harringtonine has antitumor and antiviral activities.
Harringtonine
🥰Excellent
Purity: 98.94%
Catalog No. T8286Cas No. 26833-85-2
Harringtonine is a naturally occurring alkaloid that inhibits DNA synthesis and protein synthesis and strongly kills S-phase cells. Harringtonine has antitumor and antiviral activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $37 | In Stock | |
| 5 mg | $79 | In Stock | |
| 10 mg | $119 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $296 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $92 | In Stock |
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Purity:98.94%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Harringtonine is a naturally occurring alkaloid that inhibits DNA synthesis and protein synthesis and strongly kills S-phase cells. Harringtonine has antitumor and antiviral activities. |
| In vitro | Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit, blocking aminoacyl-tRNA binding and peptide bond formation [1]. It displays potent inhibition of Chikungunya virus infection (EC50: 0.24 μM) and could inhibit other alphaviruses [2]. Additionally, Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations [3]. |
| In vivo | METHODS: To study in vivo activity, Harringtonine (0.5-4 mg/mouse) was injected retroorbital into C57BL/6 mice. RESULTS: Within 5 min, Harringtonine completely depleted multimers in all organs except testis and brain, and it took up to 30 min to significantly reduce the number of multimers due to the blood-brain and blood-testis barriers. [3] |
| Molecular Weight | 531.59 |
| Formula | C28H37NO9 |
| Cas No. | 26833-85-2 |
| Smiles | COC(=O)C[C@](O)(CCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC |
| Relative Density. | 1.35 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (103.46 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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