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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $97 | In Stock | |
5 mg | $239 | In Stock | |
10 mg | $372 | In Stock | |
25 mg | $653 | In Stock | |
50 mg | $892 | In Stock | |
100 mg | $1,230 | In Stock | |
1 mL x 10 mM (in DMSO) | $243 | In Stock |
Description | HSP70-IN-1 is a heat shock protein (HSP) inhibitor that suppresses the growth of Kasumi-1 cells with an IC50 of 2.3 μM. |
Targets&IC50 | HSP:2.3 μM |
In vitro | Heat shock protein 70 (Hsp70) functions as a molecular chaperone crucial for protein homeostasis, cell signaling, and survival, with its overexpression observed in cancer contributing to chemotherapy resistance. HSP70-IN-1 disrupts this by dose-dependently affecting the formation and stability of the Hsp70-HOP-Hsp90 complex, crucial for cancer cell survival, including altering components of this megacomplex and destabilizing the Hsp70-Hsp90 machinery client, Raf-1. It also inhibits the refolding capability of endogenous and transfected Hsp70 for heat-denatured luciferase in cells, and induces apoptosis in cancer cells by modifying the Hsp70-HOP complex formation and stability, leading to their reduced half-life. |
Molecular Weight | 464.58 |
Formula | C24H28N6O2S |
Cas No. | 1268273-90-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (96.86 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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