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ICA-27243

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Purity:99.79%

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COA HPLC HNMR

ICA-27243

Catalog No. T15545Cas No. 325457-89-4

ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.

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Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$56	In Stock
10 mg	$89	In Stock
25 mg	$179	In Stock
50 mg	$313	In Stock
100 mg	$455	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Product Introduction

Bioactivity

Description	ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.
In vitro	ICA-27243 increases both 86Rb+ efflux (EC50 = 0.2 μM) and whole-cell currents in Chinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50 = 0.4 μM). ICA-27243 produces membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors XE-991 and Linopirdine, in SH-SY5Y human neuroblastoma cells [1].
In vivo	In the mouse maximal electroshock epilepsy model, ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50: 8.4 mg/kg)[1].

Chemical Properties

Molecular Weight	268.65
Formula	C12H7ClF2N2O
Cas No.	325457-89-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 247 mg/mL (919.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7223 mL	18.6116 mL	37.2232 mL	186.1158 mL
5 mM	0.7445 mL	3.7223 mL	7.4446 mL	37.2232 mL
10 mM	0.3722 mL	1.8612 mL	3.7223 mL	18.6116 mL
20 mM	0.1861 mL	0.9306 mL	1.8612 mL	9.3058 mL
50 mM	0.0744 mL	0.3722 mL	0.7445 mL	3.7223 mL
100 mM	0.0372 mL	0.1861 mL	0.3722 mL	1.8612 mL

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