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IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 53 € | In Stock | |
5 mg | 139 € | In Stock | |
10 mg | 216 € | In Stock | |
25 mg | 376 € | In Stock | |
50 mg | 533 € | In Stock | |
100 mg | 723 € | In Stock | |
500 mg | 1.453 € | In Stock | |
1 mL x 10 mM (in DMSO) | 210 € | In Stock |
Description | IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression |
In vitro | IMM-H007 (H007) significantly inhibits monocyte adhesion to endothelial cells and its transendothelial migration.?Mechanistically, H007 markedly represses TNFα-induced IκBα degradation and NF-κB nuclear translocation, therefore leading to NF-κB-mediated inflammatory suppression.?Moreover, another inflammatory signaling JNK/c-Jun, which is always co-activated with NF-κB in response to pro-inflammatory stimuli, is also found to be restrained by H007 through reducing its phosphorylation status.?H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. |
Molecular Weight | 485.45 |
Formula | C22H23N5O8 |
Cas No. | 1221412-23-2 |
Smiles | O(C(C)=O)[C@H]1[C@@H](O[C@H](COC(C)=O)[C@H]1OC(C)=O)N2C=3C(N=C2)=C(NC4=CC(O)=CC=C4)N=CN3 |
Relative Density. | 1.54 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (60.91 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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