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IMT1B

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Catalog No. T8842Cas No. 2304621-06-3
Alias LDC203974, 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-

IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression and conferring anti-tumor properties.

IMT1B

IMT1B

🥰Excellent
Purity: 99.64%
Catalog No. T8842Alias LDC203974, 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-Cas No. 2304621-06-3
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression and conferring anti-tumor properties.
Pack SizePriceAvailabilityQuantity
1 mg$148In Stock
5 mg$328In Stock
10 mg$562In Stock
25 mg$815In Stock
50 mg$987In Stock
100 mg$1,390In Stock
1 mL x 10 mM (in DMSO)$343In Stock
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Purity:99.64%
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Product Introduction

Bioactivity
Description
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression and conferring anti-tumor properties.
AliasLDC203974, 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-
Chemical Properties
Molecular Weight473.88
FormulaC24H21ClFNO6
Cas No.2304621-06-3
SmilesC[C@@H](Oc1ccc2c(cc(=O)oc2c1)-c1ccc(F)cc1Cl)C(=O)N1CCC[C@@H](C1)C(O)=O
Relative Density.1.426 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 250 mg/mL (527.56 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1102 mL10.5512 mL21.1024 mL105.5119 mL
5 mM0.4220 mL2.1102 mL4.2205 mL21.1024 mL
10 mM0.2110 mL1.0551 mL2.1102 mL10.5512 mL
20 mM0.1055 mL0.5276 mL1.0551 mL5.2756 mL
50 mM0.0422 mL0.2110 mL0.4220 mL2.1102 mL
100 mM0.0211 mL0.1055 mL0.2110 mL1.0551 mL

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