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Indeglitazar

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Purity:99.73%

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COA HNMR HPLC

Indeglitazar

Catalog No. T15575Cas No. 835619-41-5

Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$64	In Stock
25 mg	$129	In Stock
50 mg	$197	In Stock
100 mg	$297	In Stock
200 mg	$455	In Stock

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Product Introduction

Bioactivity

Description	Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).
In vitro	Measuring in part functional insulin sensitization capability of the cells, Indeglitazar shows an EC50 of 0.32 μM compared with Rosiglitazone, which shows an EC50 of 13 nM, in an assay of preadipocyte differentiation[1].
In vivo	In Zucker rat model of diabetes, Indeglitazar (10 mg/kg; i.v.) significantly lowers the levels of glucose, HbA1C, triglycerides. In the ob/ob model of diabetes and insulin resistance, Indeglitazar significantly decreases glucose, insulin, triglycerides, and free fatty acid levels. The level of Adiponectin (day 21) is essentially unchanged, thus the observed reductions in glucose and HbA1C are achieved in an adiponectin-independent fashion[1].
Alias	PPM 204

Chemical Properties

Molecular Weight	389.42
Formula	C19H19NO6S
Cas No.	835619-41-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (231.1 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5679 mL	12.8396 mL	25.6792 mL	128.3961 mL
5 mM	0.5136 mL	2.5679 mL	5.1358 mL	25.6792 mL
10 mM	0.2568 mL	1.2840 mL	2.5679 mL	12.8396 mL
20 mM	0.1284 mL	0.6420 mL	1.2840 mL	6.4198 mL
50 mM	0.0514 mL	0.2568 mL	0.5136 mL	2.5679 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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