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Indeglitazar

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Catalog No. T15575Cas No. 835619-41-5
Alias PPM 204

Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).

Indeglitazar

Indeglitazar

🥰Excellent
Purity: 99.73%
Catalog No. T15575Alias PPM 204Cas No. 835619-41-5
Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$48In Stock
10 mg$64In Stock
25 mg$129In Stock
50 mg$197In Stock
100 mg$297In Stock
200 mg$455In Stock
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Purity:99.73%
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Product Introduction

Bioactivity
Description
Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).
In vitro
Measuring in part functional insulin sensitization capability of the cells, Indeglitazar shows an EC50 of 0.32 μM compared with Rosiglitazone, which shows an EC50 of 13 nM, in an assay of preadipocyte differentiation[1].
In vivo
In Zucker rat model of diabetes, Indeglitazar (10 mg/kg; i.v.) significantly lowers the levels of glucose, HbA1C, triglycerides. In the ob/ob model of diabetes and insulin resistance, Indeglitazar significantly decreases glucose, insulin, triglycerides, and free fatty acid levels. The level of Adiponectin (day 21) is essentially unchanged, thus the observed reductions in glucose and HbA1C are achieved in an adiponectin-independent fashion[1].
AliasPPM 204
Chemical Properties
Molecular Weight389.42
FormulaC19H19NO6S
Cas No.835619-41-5
SmilesCOc1ccc(cc1)S(=O)(=O)n1cc(CCC(O)=O)c2cc(OC)ccc12
Relative Density.1.34 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (231.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5679 mL12.8396 mL25.6792 mL128.3961 mL
5 mM0.5136 mL2.5679 mL5.1358 mL25.6792 mL
10 mM0.2568 mL1.2840 mL2.5679 mL12.8396 mL
20 mM0.1284 mL0.6420 mL1.2840 mL6.4198 mL
50 mM0.0514 mL0.2568 mL0.5136 mL2.5679 mL
100 mM0.0257 mL0.1284 mL0.2568 mL1.2840 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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