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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $537 | In Stock | |
5 mg | $1,190 | In Stock | |
10 mg | $1,590 | In Stock | |
25 mg | $2,390 | In Stock | |
50 mg | $3,220 | In Stock | |
1 mL x 10 mM (in DMSO) | $1,490 | In Stock |
Description | Inecalcitol (TX 522) is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM. |
In vitro | A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow[1]. |
In vivo | Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3[1]. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo. |
Alias | TX 522, TX-522, TX522 |
Molecular Weight | 400.59 |
Formula | C26H40O3 |
Cas No. | 163217-09-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/ml (137.3 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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