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IU1-47
🥰Excellent
Catalog No. T15604Cas No. 670270-31-2
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
IU1-47
🥰Excellent
Purity: 99.55%
Catalog No. T15604Cas No. 670270-31-2
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $51 | In Stock | |
| 2 mg | $74 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $189 | In Stock | |
| 25 mg | $388 | In Stock | |
| 50 mg | $577 | In Stock | |
| 100 mg | $826 | In Stock | |
| 500 mg | $1,680 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $133 | In Stock |
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Purity:99.55%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM). |
| Targets&IC50 | USP14:0.6 μM, IsoT/USP5:20 μM |
| In vitro | IU1-47 stimulates tau degradation principally via the ubiquitin-proteasome system. IU1-47 is essentially inactive on free USP14. IU1-47 (25 μM) antagonizes USP14 deubiquitinating activity and stimulates substrate degradation in vitro. IU1-47 (3 μM, 10, and 30 μM; 48 hours) obviously reduces Tau and phosphatase species Ser-202/Thr-205 levels in murine cortical primary neurons. |
| Molecular Weight | 330.85 |
| Formula | C19H23ClN2O |
| Cas No. | 670270-31-2 |
| Smiles | Cc1cc(C(=O)CN2CCCCC2)c(C)n1-c1ccc(Cl)cc1 |
| Relative Density. | 1.18 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (27.2 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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