Shopping Cart
- Remove All
Your shopping cart is currently empty
JNJ-63576253 free base
🥰Excellent
Catalog No. T8933Cas No. 2110426-27-0
Alias TRC253, JNJ-63576253
JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).
JNJ-63576253 free base
🥰Excellent
Purity: 98.32%
Catalog No. T8933Alias TRC253, JNJ-63576253Cas No. 2110426-27-0
JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $34 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $82 | In Stock | |
| 25 mg | $170 | In Stock | |
| 50 mg | $271 | In Stock | |
| 100 mg | $398 | In Stock | |
| 200 mg | $568 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $83 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "JNJ-63576253 free base"
Flutamide
Cited
SCH 13521
T048913311-84-7
Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
- $30
Size
QTY
CitedEnzalutamide
Cited
MDV3100
T6002915087-33-1
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP) that activates autophagy, exhibits antitumor activity, and is commonly used in treating desmoplasia-resistant prostate cancer.
- $40
Size
QTY
CitedS-23
S23, (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
T207891010396-29-8
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
- $39
Size
QTY
Dehydroisoandrosterone 3-acetate
Prasterone acetate, DHEA acetate, Dehydroepiandrosterone acetate, Dehydroepiandrosterone 3-acetate, androstenolone acetate
T0856853-23-6
Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.
- $41
Size
QTY
Allura Red AC
FD&C RED NO. 40, CI 16035, Allura Red
TN137025956-17-6
Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.
- $50
Size
QTY
Sunset Yellow FCF
Sunset yellow, Orange Yellow S, Food Yellow 3, CI 15985
TN22452783-94-0
Sunset Yellow FCF (Sunset yellow) is an orange azo dye with pH-dependent absorbance.Sunset Yellow FCF is used in food, cosmetics and pharmaceuticals.It is used as a colorant food additive in many food products.They may be cytotoxic and genotoxic, so care must be taken when using these materials as food additives.
- $41
Size
QTY
Octinoxate
Octyl methoxycinnamate, Octyl 4-methoxycinnamate, ethylhexyl methoxycinnamate, 2-Ethylhexyl 4-methoxycinnamate
T00735466-77-3
Octinoxate (Octyl 4-methoxycinnamate) is used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage,primarily as an ingredient in some sunscreens and lip balms. It is also used to reduce the appearance of scars.
- $41
Size
QTY
Ostarine
MK-2866, GTX-024, Enobosarm
T2408841205-47-8
Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.
- $36
Size
QTY
Bicalutamide
ICI-176334
T038090357-06-5
Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
- $32
Size
QTY
Bavdegalutamide Cited
ARV-110
T222632222112-77-6
Bavdegalutamide (ARV-110) is an oral protein degrader that specifically binds to AR and mediates its degradation. Bavdegalutamide can degrade clinically relevant mutant AR proteins, maintain activity in a high androgen environment, and has an acceptable safety profile.
- $85
Size
QTY
CitedMedroxyprogesterone Acetate Cited
Provera, NSC-26386, Metigestrona, Medroxyprogesterone 17-acetate, Medroxyprogesterone (acetate), Farlutin
T126171-58-9
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
Androgen ReceptorEndogenous MetaboliteEstrogen/progestogen ReceptorGlucocorticoid ReceptorProgesterone Receptor
- $30
Size
QTY
CitedAdrenosterone
Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedione
T2207382-45-6
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
- $39
Size
QTY
Select Batch
Purity:98.32%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC). |
| Targets&IC50 | Androgen receptor:37 nM(F877L mutant AR in LNCaP cells), Androgen receptor:54 nM(wild-type AR in LNCaP cells) |
| In vitro | JNJ-63576253 is stable in human liver microsomes, with an T1/2 of >180 min. It(0.0003-100 μM; 5 d) inhibits the growth of VCaP cells, with an IC50 of 265 nM. |
| In vivo | JNJ-63576253 (30 mg/kg;?p.o. once daily for 72 days) significantly inhibits the growth of prostate LNCaP SRα F877L tumor in mice.?JNJ-63576253 (30 mg/kg;?p.o. once daily for 10 days) inhibits the five androgen sensitive organs (ASOs) under stimulation by testosterone propionate (TP) in mice.?JNJ-63576253 (10 mg/kg;?p.o.) exhibits moderate oral bioavailability (45%), Cmax (0.66 μM) and AUClast (4.9 μg h/mL) in mice.?JNJ-63576253 (2 mg/kg;?i.v.) exhibits reasonable half-life (5.99 h), CL (15.0 mL/min/kg) and Vdss (6.11 L/kg) in mice. |
| Alias | TRC253, JNJ-63576253 |
| Molecular Weight | 502.51 |
| Formula | C23H21F3N6O2S |
| Cas No. | 2110426-27-0 |
| Smiles | FC(F)(F)c1cc(cnc1C#N)N1C(=S)N(c2ccc(OC3CCNCC3)nc2)C2(CCC2)C1=O |
| Relative Density. | 1.53 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (89.55 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy JNJ-63576253 free base | purchase JNJ-63576253 free base | JNJ-63576253 free base cost | order JNJ-63576253 free base | JNJ-63576253 free base chemical structure | JNJ-63576253 free base in vivo | JNJ-63576253 free base in vitro | JNJ-63576253 free base formula | JNJ-63576253 free base molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.