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JNJ-63576253

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Purity:99.27%

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COA LCMS HNMR

JNJ-63576253

Catalog No. T9246Cas No. 2110428-64-1

JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).

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Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$113	In Stock
25 mg	$247	In Stock
50 mg	$396	In Stock
100 mg	$589	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock

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Product Introduction

Bioactivity

Description	JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
In vitro	JNJ-63576253 inhibits the growth of VCaP cells,with an IC50 of 265nM[1].

Chemical Properties

Molecular Weight	538.97
Formula	C23H22ClF3N6O2S
Cas No.	2110428-64-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200mg/mL (371.08 mM)

H2O: insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8554 mL	9.2770 mL	18.5539 mL	92.7695 mL
5 mM	0.3711 mL	1.8554 mL	3.7108 mL	18.5539 mL
10 mM	0.1855 mL	0.9277 mL	1.8554 mL	9.2770 mL
20 mM	0.0928 mL	0.4638 mL	0.9277 mL	4.6385 mL
50 mM	0.0371 mL	0.1855 mL	0.3711 mL	1.8554 mL
100 mM	0.0186 mL	0.0928 mL	0.1855 mL	0.9277 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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