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KM-023

🥰Excellent
Catalog No. T67804Cas No. 1097628-00-6

KM-023 is a new second-generation non-nucleoside reverse transcriptase inhibitor for the study of human immunodeficiency virus (HIV) type 1 infection.

KM-023

KM-023

🥰Excellent
Purity: 100%
Catalog No. T67804Cas No. 1097628-00-6
KM-023 is a new second-generation non-nucleoside reverse transcriptase inhibitor for the study of human immunodeficiency virus (HIV) type 1 infection.
Pack SizePriceAvailabilityQuantity
1 mg$153In Stock
5 mg$380In Stock
10 mg$570In Stock
25 mg$916In Stock
50 mg$1,250In Stock
100 mg$1,680In Stock
500 mg$3,370In Stock
1 mL x 10 mM (in DMSO)$377In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
KM-023 is a new second-generation non-nucleoside reverse transcriptase inhibitor for the study of human immunodeficiency virus (HIV) type 1 infection.
In vivo
KM-023 demonstrated dose- and time-dependent nonlinear pharmacokinetic characteristics after single or multiple doses over a dose range (75-600 mg) in healthy subjects. KM-023 showed a 0.6-fold accumulation after multiple doses in the 600 mg dose group. The mean half-life values ranged between 20.7 and 31.2 hours. KM-023 was generally well tolerated without serious adverse events. KM-023 showed favorable tolerability in this study.[1]
Chemical Properties
Molecular Weight325.36
FormulaC18H19N3O3
Cas No.1097628-00-6
SmilesC(=O)(C1=C(C(C)C)C(=O)NC(=O)N1CC)C2=CC(C#N)=CC(C)=C2
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 11 mg/mL (33.81 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0735 mL15.3676 mL30.7352 mL153.6759 mL
5 mM0.6147 mL3.0735 mL6.1470 mL30.7352 mL
10 mM0.3074 mL1.5368 mL3.0735 mL15.3676 mL
20 mM0.1537 mL0.7684 mL1.5368 mL7.6838 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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