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KS176

KS176
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Purity:99.78%
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KS176

Catalog No. T3581Cas No. 1253452-78-6
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, exhibiting no inhibitory activity against P-gp or MRP1.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$37In Stock
2 mg$50In Stock
5 mg$79In Stock
10 mg$133In Stock
25 mg$293In Stock
50 mg$536In Stock
100 mg$773In Stock
500 mg$1,590In Stock
1 mL x 10 mM (in DMSO)$79In Stock
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Product Introduction

Bioactivity
Description
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, exhibiting no inhibitory activity against P-gp or MRP1.
Targets&IC50
BCRP(Pheo A):0.59 μM
Kinase Assay
Phospholipase D activity is quantified using our established method of measuring the formation of [32P]-radiolabeled PBt. Cellular lipids are extracted and PBt is isolated using our published methods of lipid extraction and thin layer chromatographic separation, respectively. Radioactivity is measured using liquid scintillation counting and quantified as DPM normalized to 106 counts in the total cellular lipid extract or as percentage of control (vehicle-treated cells).
Chemical Properties
Molecular Weight405.4
FormulaC22H19N3O5
Cas No.1253452-78-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (135.67 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4667 mL12.3335 mL24.6670 mL123.3350 mL
5 mM0.4933 mL2.4667 mL4.9334 mL24.6670 mL
10 mM0.2467 mL1.2333 mL2.4667 mL12.3335 mL
20 mM0.1233 mL0.6167 mL1.2333 mL6.1667 mL
50 mM0.0493 mL0.2467 mL0.4933 mL2.4667 mL
100 mM0.0247 mL0.1233 mL0.2467 mL1.2333 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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