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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $164 | 5 days |
Description | KYN-101 is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO. |
Molecular Weight | 386.42 |
Formula | C22H19FN6 |
Cas No. | 2247950-73-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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