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L189

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Purity:99.72%

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COA HNMR LCMS

L189

Catalog No. T4517Cas No. 64232-83-3

L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).

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Pack Size	Price	Availability
2 mg	$36	In Stock
5 mg	$59	In Stock
10 mg	$91	In Stock
25 mg	$196	In Stock
50 mg	$343	In Stock
100 mg	$480	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock

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Product Introduction

Bioactivity

Description	L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
In vitro	L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.

Chemical Properties

Molecular Weight	246.29
Formula	C11H10N4OS
Cas No.	64232-83-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL

H2O: Insoluble

DMSO: 50 mg/mL (203.01 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0603 mL	20.3013 mL	40.6025 mL	203.0127 mL
5 mM	0.8121 mL	4.0603 mL	8.1205 mL	40.6025 mL
10 mM	0.4060 mL	2.0301 mL	4.0603 mL	20.3013 mL
20 mM	0.2030 mL	1.0151 mL	2.0301 mL	10.1506 mL
50 mM	0.0812 mL	0.4060 mL	0.8121 mL	4.0603 mL
100 mM	0.0406 mL	0.2030 mL	0.4060 mL	2.0301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc