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Levocetirizine Dihydrochloride
Catalog No. T22354Cas No. 130018-87-0
Alias Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
Levocetirizine Dihydrochloride
Catalog No. T22354Alias Xyzal Dihydrochloride, (-)-Cetirizine DihydrochlorideCas No. 130018-87-0
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $43 | In Stock | |
| 25 mg | $78 | In Stock | |
| 50 mg | $133 | In Stock | |
| 100 mg | $198 | In Stock | |
| 200 mg | $297 | In Stock | |
| 500 mg | $513 | In Stock | |
| 1 g | $729 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria. |
| In vivo | Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) yields a Cmax of 0.34 μg/mL, an AUC0-t of 3.26 μg h/mL, an AUC0-∞ of 3.67 μg h/mL, and a t1/2 of 2.34 hours in Sprague-Dawley rats[1]. |
| Alias | Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride |
| Molecular Weight | 461.81 |
| Formula | C21H27Cl3N2O3 |
| Cas No. | 130018-87-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 90 mg/mL (194.9 mM), Sonication is recommended. DMSO: 50 mg/mL (108.27 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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