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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
2 mg | $54 | In Stock | |
5 mg | $116 | In Stock | |
10 mg | $150 | In Stock | |
25 mg | $332 | In Stock | |
50 mg | $448 | In Stock | |
100 mg | $658 | In Stock | |
500 mg | $1,380 | In Stock | |
1 mL x 10 mM (in DMSO) | $126 | In Stock |
Description | LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM). |
In vitro | In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM[1]. Combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus, LY2584702 has significant synergistic effects [2]. |
In vivo | LY2584702 (12.5 mg/kg BID), shows significant antitumor activity in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1] |
Molecular Weight | 445.42 |
Formula | C21H19F4N7 |
Cas No. | 1082949-67-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 1 mg/mL(2.24 mM) | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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