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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $45 | In Stock | |
2 mg | $64 | In Stock | |
5 mg | $107 | In Stock | |
10 mg | $169 | In Stock | |
25 mg | $317 | In Stock | |
50 mg | $513 | In Stock | |
100 mg | $743 | In Stock | |
500 mg | $1,550 | In Stock | |
1 mL x 10 mM (in DMSO) | $118 | In Stock |
Description | LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
In vitro | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells. LY3200882 has shown anti-metastatic activity in vitro in migration assays. In in vitro immune suppression assays, LY3200882 has shown the ability to rescue TGFβ1 suppressed or T regulatory cell suppressed na?ve T cell activity and restore proliferation [1]. |
In vivo | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose-dependent fashion. LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer) [1]. |
Molecular Weight | 435.52 |
Formula | C24H29N5O3 |
Cas No. | 1898283-02-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 4.36 mg/mL (10 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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