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LY3200882
🥰Excellent
Catalog No. T5125Cas No. 1898283-02-7
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
LY3200882
🥰Excellent
Purity: 99.46%
Catalog No. T5125Cas No. 1898283-02-7
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | $455 | In Stock | |
| 100 mg | $689 | In Stock |
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Purity:99.46%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
| Targets&IC50 | TGFβRI:38.2 nM (IC50) |
| In vitro | LY3200882 effectively inhibits TGFβ-mediated SMAD phosphorylation in tumor and immune cells in vitro, demonstrates anti-metastatic activity in migration assays, and rescues TGFβ1 or T regulatory cell-suppressed naive T cell activity, restoring proliferation in immune suppression assays [1]. |
| In vivo | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose-dependent fashion. LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer) [1]. |
| Molecular Weight | 435.52 |
| Formula | C24H29N5O3 |
| Cas No. | 1898283-02-7 |
| Smiles | CC(C)(O)c1cc(Nc2cc(Oc3cn(nc3C3CCOCC3)C3CC3)ccn2)ccn1 |
| Relative Density. | 1.36 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.36 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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