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Metixene hydrochloride hydrate

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Purity:99.88%

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COA HPLC HNMR

Metixene hydrochloride hydrate

Catalog No. TQ0304Cas No. 7081-40-5

Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.

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Pack Size	Price	Availability
5 mg	$35	In Stock
10 mg	$55	In Stock
25 mg	$113	In Stock
50 mg	$178	In Stock
100 mg	$289	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Product Introduction

Bioactivity

Description	Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.
In vitro	Metixene hydrochloride hydrate, with IC50 and Ki values of 55 nM and 15 nM, respectively, has the potential to inhibit the binding of QNB with the muscarinic receptor [1].

Chemical Properties

Molecular Weight	363.95
Formula	C20H26ClNOS
Cas No.	7081-40-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 5 mg/mL (13.74c)

DMSO: 70 mg/mL (192.34 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7476 mL	13.7382 mL	27.4763 mL	137.3815 mL
5 mM	0.5495 mL	2.7476 mL	5.4953 mL	27.4763 mL
10 mM	0.2748 mL	1.3738 mL	2.7476 mL	13.7382 mL
20 mM	0.1374 mL	0.6869 mL	1.3738 mL	6.8691 mL
50 mM	0.0550 mL	0.2748 mL	0.5495 mL	2.7476 mL
100 mM	0.0275 mL	0.1374 mL	0.2748 mL	1.3738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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