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BPHA

🥰Excellent
Catalog No. T36712Cas No. 193807-60-2
Alias MMP-2/MMP-9 Inhibitor II

BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities.

BPHA

BPHA

🥰Excellent
Purity: 99.72%
Catalog No. T36712Alias MMP-2/MMP-9 Inhibitor IICas No. 193807-60-2
BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities.
Pack SizePriceAvailabilityQuantity
1 mg$215In Stock
5 mg$593In Stock
10 mg$848In Stock
25 mg$1,290In Stock
50 mg$1,730In Stock
100 mg$2,330In Stock
500 mg$4,690In Stock
1 mL x 10 mM (in DMSO)$611In Stock
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Purity:99.72%
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Product Introduction

Bioactivity
Description
BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities.
Targets&IC50
MMP1:974 nM, MMP2:12 nM, MMP7:795 nM, MMP9:16 nM, MMP14:17 nM, MMP3:>1000 nM
In vivo
Administration of BPHA (200 mg/kg; via oral; daily) in mice effectively suppresses tumor-induced angiogenesis, primary tumor growth, and liver metastasis. BPHA exhibits remarkable growth inhibitory activity of 48% and 45% in the B16-BL6 melanoma and F2 hemangio-endothelioma models, respectively.[1]
AliasMMP-2/MMP-9 Inhibitor II
Chemical Properties
Molecular Weight396.46
FormulaC21H20N2O4S
Cas No.193807-60-2
SmilesS(N[C@H](CC1=CC=CC=C1)C(NO)=O)(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Methanol: 22.5 mg/mL (56.8 mM)
DMSO: 90.0 mg/mL (227.0 mM)
Solution Preparation Table
Methanol/DMSO
1mg5mg10mg50mg
1 mM2.5223 mL12.6116 mL25.2232 mL126.1161 mL
5 mM0.5045 mL2.5223 mL5.0446 mL25.2232 mL
10 mM0.2522 mL1.2612 mL2.5223 mL12.6116 mL
20 mM0.1261 mL0.6306 mL1.2612 mL6.3058 mL
50 mM0.0504 mL0.2522 mL0.5045 mL2.5223 mL
DMSO
1mg5mg10mg50mg
100 mM0.0252 mL0.1261 mL0.2522 mL1.2612 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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