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Mometasone furoate
Catalog No. T1531Cas No. 83919-23-7
Alias Sch32088
Mometasone furoate (Sch32088) is a pregnadienediol derivative with anti-allergic and anti-inflammatory properties, used in the management of asthma and allergic rhinitis, as well as a topical treatment for skin disorders.
Mometasone furoate
Catalog No. T1531Alias Sch32088Cas No. 83919-23-7
Mometasone furoate (Sch32088) is a pregnadienediol derivative with anti-allergic and anti-inflammatory properties, used in the management of asthma and allergic rhinitis, as well as a topical treatment for skin disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $39 | In Stock | |
| 50 mg | $48 | In Stock | |
| 100 mg | $88 | In Stock | |
| 200 mg | $108 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Purity:99.48%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Mometasone furoate (Sch32088) is a pregnadienediol derivative with anti-allergic and anti-inflammatory properties, used in the management of asthma and allergic rhinitis, as well as a topical treatment for skin disorders. |
| In vitro | Both 0.02% Mometasone furoate and 0.1% Fluticasone propionate significantly suppress the increase in antigen-induced nasal rubbing even six hours after topical application, demonstrating their lasting effects. Mometasone furoate reduces nasal rubbing in rats and, at the highest tested dose in mice (3mg/kg), inhibits the increased sensitivity to aerosolized acetylcholine. The compound dose-dependently suppresses the elevation of eosinophil counts in the bronchoalveolar lavage fluid and lung tissue of mice challenged with sensitizing ovalbumin. Furthermore, a dosage of 33 mg/kg Mometasone furoate lowers the percentage of CD44+ T helper cells (activated/memory cells) to levels observed in mice not challenged with sensitizing ovalbumin, indicating its immunomodulatory potential. |
| In vivo | Mometasone furoate effectively inhibits the production of cytokines, including interleukin (IL)-4, IL-5, and interferon-γ, in human CD4+ T cells stimulated by anti-CD3. It also efficiently suppresses the activation of Th cells, including type 2 helper T (Th2) cells, in draining lymph nodes, leading to the suppression of the IgE response. |
| Alias | Sch32088 |
| Molecular Weight | 521.43 |
| Formula | C27H30Cl2O6 |
| Cas No. | 83919-23-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (86.3 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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