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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $33 | In Stock | |
10 mg | $46 | In Stock | |
25 mg | $75 | In Stock | |
50 mg | $109 | In Stock | |
100 mg | $163 | In Stock | |
200 mg | $243 | In Stock | |
500 mg | $397 | In Stock | |
1 g | $588 | In Stock | |
1 mL x 10 mM (in DMSO) | $43 | In Stock |
Description | MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) |
In vitro | SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD. MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.[1]. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity[3]. |
Molecular Weight | 297.13 |
Formula | C12H12IN |
Cas No. | 36913-39-0 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 100 mg/mL (336.54 mM), Sonication is recommended. DMSO: 50 mg/mL (168.28 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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