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MRT68921 dihydrochloride

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Purity:100%

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COA HNMR HPLC

MRT68921 dihydrochloride

Catalog No. T9142Cas No. 2080306-21-2

MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).

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Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$56	In Stock
10 mg	$94	In Stock
25 mg	$197	In Stock
50 mg	$357	In Stock
100 mg	$467	In Stock
200 mg	$687	In Stock

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Product Introduction

Bioactivity

Description

MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).

In vitro

MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells.?MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm).?Autophagy-inhibiting capacity of the compounds is specifically through ULK1.?ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation[1]

Chemical Properties

Molecular Weight	507.499
Formula	C25H36Cl2N6O
Cas No.	2080306-21-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 33.33 mg/mL (65.67 mM)

DMSO: 2 mg/mL (3.94 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9704 mL	9.8522 mL	19.7045 mL	98.5224 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.3941 mL	1.9704 mL	3.9409 mL	19.7045 mL
10 mM	0.1970 mL	0.9852 mL	1.9704 mL	9.8522 mL
20 mM	0.0985 mL	0.4926 mL	0.9852 mL	4.9261 mL
50 mM	0.0394 mL	0.1970 mL	0.3941 mL	1.9704 mL
100 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.9852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc