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NF-κΒ activator 2

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COA HNMR HPLC

NF-κΒ activator 2

Catalog No. T39924Cas No. 2375281-44-8

NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1].

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Pack Size	Price	Availability
1 mg	$158	In Stock
5 mg	$397	In Stock
10 mg	$589	In Stock
25 mg	$945	In Stock
50 mg	$1,280	In Stock
100 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$437	In Stock

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Product Introduction

Bioactivity

Description	NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1].
In vitro	NF-κB activator 2 (Compound 61) (1 μM, 6 hr) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells [1]. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through the activation of NF-ҡBs.
In vivo	NF-κΒ activator 2, when administered intravenously (i.v.) at a dose of 1 mg/kg, demonstrates an appropriate half-life of 0.96 hours in mice [1]. Similarly, at an oral (p.o.) dosage of 5 mg/kg, it shows a comparable half-life of 2.86 hours, an oral bioavailability of 15.6%, and a maximum concentration (C max) of 92 ng/mL [1].

Chemical Properties

Molecular Weight	298.27
Formula	C16H11FN2O3
Cas No.	2375281-44-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (838.17 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3527 mL	16.7633 mL	33.5267 mL	167.6334 mL
5 mM	0.6705 mL	3.3527 mL	6.7053 mL	33.5267 mL
10 mM	0.3353 mL	1.6763 mL	3.3527 mL	16.7633 mL
20 mM	0.1676 mL	0.8382 mL	1.6763 mL	8.3817 mL
50 mM	0.0671 mL	0.3353 mL	0.6705 mL	3.3527 mL
100 mM	0.0335 mL	0.1676 mL	0.3353 mL	1.6763 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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