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NMI 8739

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Purity:98.51%

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COA HNMR LCMS

NMI 8739

Catalog No. T11079Cas No. 129024-87-9

NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.

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Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$95	In Stock
10 mg	$133	In Stock
25 mg	$217	In Stock
50 mg	$318	In Stock
100 mg	$472	In Stock
500 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock

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Product Introduction

Bioactivity

Description	NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
In vitro	NMI 8739 (2 μM) significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectivel. NMI 8739 suppresses the production of PGE2 in a concentration-dependent manner with 25.3%, 75% reduction at doses of 100 nM and 1 μM, respectively[2].
Alias	n-docosahexaenoyl dopamine, Dha-DA conjugate

Chemical Properties

Molecular Weight	463.65
Formula	C30H41NO3
Cas No.	129024-87-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 90 mg/mL (194.1 mM)

DMSO: 90 mg/mL (194.1 mM)

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.1568 mL	10.7840 mL	21.5680 mL	107.8400 mL
5 mM	0.4314 mL	2.1568 mL	4.3136 mL	21.5680 mL
10 mM	0.2157 mL	1.0784 mL	2.1568 mL	10.7840 mL
20 mM	0.1078 mL	0.5392 mL	1.0784 mL	5.3920 mL
50 mM	0.0431 mL	0.2157 mL	0.4314 mL	2.1568 mL
100 mM	0.0216 mL	0.1078 mL	0.2157 mL	1.0784 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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