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NRX-252262 is a potent enhancer of the interaction between β-Catenin and its cognate E3 ligase, SCFβ-TrCP, inducing mutant β-Catenin degradation (EC50: 3.8 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $116 | In Stock | |
5 mg | $287 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $753 | In Stock | |
50 mg | $1,060 | In Stock | |
100 mg | $1,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $347 | In Stock |
Description | NRX-252262 is a potent enhancer of the interaction between β-Catenin and its cognate E3 ligase, SCFβ-TrCP, inducing mutant β-Catenin degradation (EC50: 3.8 nM). |
Targets&IC50 | β-catenin/SCFβ-TrCP:3.8 nM (EC50) |
In vitro | NRX-252262 also induces S33E/S37A mutant β-catenin degradation at an even lower concentration of ~35?μM |
Molecular Weight | 545.36 |
Formula | C23H17Cl2F3N2O4S |
Cas No. | 2438637-61-5 |
Smiles | COc1cc2CN(Cc2cc1OC)C(=O)c1c(Sc2c(Cl)cccc2Cl)cc([nH]c1=O)C(F)(F)F |
Relative Density. | 1.57 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 8 mg/mL (14.67 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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