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Olmutinib

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Purity:97.46%

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COA HNMR HPLC

Olmutinib

Catalog No. T8460Cas No. 1802181-20-9

Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$52	In Stock
10 mg	$85	In Stock
25 mg	$133	In Stock
50 mg	$195	In Stock
100 mg	$297	In Stock
200 mg	$488	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock

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Product Introduction

Bioactivity

Description	Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
In vitro	Olmutinib at 3 μM significantly reversed drug resistance mediated by ABCG2, but not by ABCB1 and ABCC1, by antagonizing the drug efflux function in ABCG2-overexpressing cells.?In addition, olmutinib at reversal concentration affected neither the protein expression level nor the localization of ABCG2.?The results observed from the accumulation/efflux study of olmutinib showed that olmutinib reversed ABCG2-mediated MDR with an increasing intracellular drug accumulation due to inhibited drug efflux.?We also had consistent results with the ATPase assay that olmutinib stimulated ATPase activity of ABCG2 up to 3.5-fold.?Additionally, the molecular interaction between olmutinib and ABCG2 was identified by docking simulation.?Olmutinib not only interacts directly with ABCG2 but also works as a competitive inhibitor of the transport protein[1]
Alias	HM61713, BI1482694

Chemical Properties

Molecular Weight	486.59
Formula	C26H26N6O2S
Cas No.	1802181-20-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (113.03 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0551 mL	10.2756 mL	20.5512 mL	102.7559 mL
5 mM	0.4110 mL	2.0551 mL	4.1102 mL	20.5512 mL
10 mM	0.2055 mL	1.0276 mL	2.0551 mL	10.2756 mL
20 mM	0.1028 mL	0.5138 mL	1.0276 mL	5.1378 mL
50 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0551 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc