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PAT-1251

Catalog No. T12371LCas No. 2007885-39-2

PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.

PAT-1251

PAT-1251

Purity: 99.78%
Catalog No. T12371LCas No. 2007885-39-2
PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
Pack SizePriceAvailabilityQuantity
1 mg$118In Stock
5 mg$298In Stock
10 mg$433In Stock
25 mg$678In Stock
50 mg$912In Stock
100 mg$1,180In Stock
200 mg$1,580In Stock
1 mL x 10 mM (in DMSO)$328In Stock
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Purity:99.78%
ee:100%
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Product Introduction

Bioactivity
Description
PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
Targets&IC50
LOXL2 (mouse):0.10 μM, LOXL2 (human):0.71 μM, LOXL2 (rat):0.12 μM, LOXL2 (dog):0.16 μM, LOXL3 (human):1.17 μM
In vitro
PAT-1251 inhibits hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM. PAT-1251 shows highly selective for LOXL2 over other amine oxidases, such as SSAO, DAO, MAO-A, and MAO-B with <10% inhibition at 10 μM[1].
Chemical Properties
Molecular Weight399.34
FormulaC18H17F4N3O3
Cas No.2007885-39-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 117.0 mg/mL (293.0 mM)
H2O: 90.0 mg/mL (225.4 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.5041 mL12.5207 mL25.0413 mL125.2066 mL
5 mM0.5008 mL2.5041 mL5.0083 mL25.0413 mL
10 mM0.2504 mL1.2521 mL2.5041 mL12.5207 mL
20 mM0.1252 mL0.6260 mL1.2521 mL6.2603 mL
50 mM0.0501 mL0.2504 mL0.5008 mL2.5041 mL
100 mM0.0250 mL0.1252 mL0.2504 mL1.2521 mL

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