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PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $118 | In Stock | |
5 mg | $298 | In Stock | |
10 mg | $433 | In Stock | |
25 mg | $678 | In Stock | |
50 mg | $912 | In Stock | |
100 mg | $1,180 | In Stock | |
200 mg | $1,580 | In Stock | |
1 mL x 10 mM (in DMSO) | $328 | In Stock |
Description | PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases. |
Targets&IC50 | LOXL2 (mouse):0.10 μM, LOXL2 (human):0.71 μM, LOXL2 (rat):0.12 μM, LOXL2 (dog):0.16 μM, LOXL3 (human):1.17 μM |
In vitro | PAT-1251 inhibits hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM. PAT-1251 shows highly selective for LOXL2 over other amine oxidases, such as SSAO, DAO, MAO-A, and MAO-B with <10% inhibition at 10 μM[1]. |
Molecular Weight | 399.34 |
Formula | C18H17F4N3O3 |
Cas No. | 2007885-39-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 117.0 mg/mL (293.0 mM) H2O: 90.0 mg/mL (225.4 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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