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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $197 | In Stock | |
5 mg | $497 | In Stock | |
10 mg | $723 | In Stock | |
25 mg | $1,130 | In Stock | |
50 mg | $1,520 | In Stock | |
100 mg | $1,980 | In Stock | |
500 mg | $3,970 | In Stock | |
1 mL x 10 mM (in DMSO) | $547 | In Stock |
Description | PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases. |
Targets&IC50 | LOXL2 (human):0.71 μM, LOXL2 (mouse):0.10 μM, LOXL2 (rat):0.12 μM, LOXL3 (human):1.17 μM, LOXL2 (dog):0.16 μM |
In vitro | PAT-1251 inhibits hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM. PAT-1251 shows highly selective for LOXL2 over other amine oxidases, such as SSAO, DAO, MAO-A, and MAO-B with <10% inhibition at 10 μM[1]. |
Molecular Weight | 399.34 |
Formula | C18H17F4N3O3 |
Cas No. | 2007885-39-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 117.0 mg/mL (293.0 mM) H2O: 90.0 mg/mL (225.4 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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