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PAT-1251

PAT-1251
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Purity:99.78%
ee:100%

PAT-1251

Catalog No. T12371LCas No. 2007885-39-2
PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$197In Stock
5 mg$497In Stock
10 mg$723In Stock
25 mg$1,130In Stock
50 mg$1,520In Stock
100 mg$1,980In Stock
500 mg$3,970In Stock
1 mL x 10 mM (in DMSO)$547In Stock
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Product Introduction

Bioactivity
Description
PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
Targets&IC50
LOXL2 (human):0.71 μM, LOXL2 (mouse):0.10 μM, LOXL2 (rat):0.12 μM, LOXL3 (human):1.17 μM, LOXL2 (dog):0.16 μM
In vitro
PAT-1251 inhibits hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM. PAT-1251 shows highly selective for LOXL2 over other amine oxidases, such as SSAO, DAO, MAO-A, and MAO-B with <10% inhibition at 10 μM[1].
Chemical Properties
Molecular Weight399.34
FormulaC18H17F4N3O3
Cas No.2007885-39-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 117.0 mg/mL (293.0 mM)
H2O: 90.0 mg/mL (225.4 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.5041 mL12.5207 mL25.0413 mL125.2066 mL
5 mM0.5008 mL2.5041 mL5.0083 mL25.0413 mL
10 mM0.2504 mL1.2521 mL2.5041 mL12.5207 mL
20 mM0.1252 mL0.6260 mL1.2521 mL6.2603 mL
50 mM0.0501 mL0.2504 mL0.5008 mL2.5041 mL
100 mM0.0250 mL0.1252 mL0.2504 mL1.2521 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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