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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $59 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $317 | In Stock | |
1 mL x 10 mM (in DMSO) | $66 | In Stock |
Description | PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2]. |
Targets&IC50 | μ-Calpain:260 nM, m-Calpain:5.33 μM |
In vivo | PD151746 reduces the cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells. It also effectively mitigates the hydrolysis of SLLVY-AMC induced by marine toxins in SY5Y cells. |
Molecular Weight | 237.25 |
Formula | C11H8FNO2S |
Cas No. | 179461-52-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 44 mg/mL (185.5 mM) Ethanol: 44 mg/mL (185.5 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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