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Evixapodlin

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Purity:99.07%

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COA HNMR HPLC

Evixapodlin

Catalog No. T36487Cas No. 2374856-75-2

Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.

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Pack Size	Price	Availability
1 mg	$113	In Stock
5 mg	$278	In Stock
10 mg	$447	In Stock
25 mg	$847	In Stock
50 mg	$1,130	In Stock
100 mg	$1,530	In Stock
1 mL x 10 mM (in DMSO)	$428	In Stock

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Product Introduction

Bioactivity

Description	Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.
In vitro	Evixapodlin exhibits an ability to increase the production of IFN-γ and Granzyme B in both CD8+ and CD4+ T cells in individuals with chronic hepatitis B (CHB). Additionally, Evixapodlin enhances the frequency of Granzyme B-positive cells among HBV-specific CD8+ and CD4+ T cells.[1]
In vivo	Evixapodlin (10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment results in over 90% occupancy of the PD-L1 target on tumor cells. Evixapodlin effectively suppresses tumor growth in a mouse colorectal tumor model (MC38) that expresses human PD-L1.[1]
Alias	PD-1/PD-L1-IN 7, GS-4224

Chemical Properties

Molecular Weight	691.61
Formula	C34H36Cl2N8O4
Cas No.	2374856-75-2

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (65.1 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4459 mL	7.2295 mL	14.4590 mL	72.2951 mL
5 mM	0.2892 mL	1.4459 mL	2.8918 mL	14.4590 mL
10 mM	0.1446 mL	0.7230 mL	1.4459 mL	7.2295 mL
20 mM	0.0723 mL	0.3615 mL	0.7230 mL	3.6148 mL
50 mM	0.0289 mL	0.1446 mL	0.2892 mL	1.4459 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc