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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $60 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $128 | In Stock |
Description | Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3. |
Targets&IC50 | JAK2:5.0 nM, TYK2:4.8 nM, JAK1:3.9 nM, JAK3:0.7 nM |
In vitro | ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). [1] |
In vivo | In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score. [1] |
Alias | ASP015K, JNJ-54781532 |
Molecular Weight | 326.39 |
Formula | C18H22N4O2 |
Cas No. | 944118-01-8 |
Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: <1 mg/mL Ethanol: <1 mg/mL DMSO: 60 mg/mL (183.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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