Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

PF-06726304

🥰Excellent
Catalog No. T12428LCas No. 1616287-82-1

PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).

PF-06726304

PF-06726304

🥰Excellent
Purity: 98.3%
Catalog No. T12428LCas No. 1616287-82-1
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
2 mg$46In Stock
5 mg$74In Stock
10 mg$127In Stock
25 mg$293In Stock
50 mg$531In Stock
100 mg$768In Stock
1 mL x 10 mM (in DMSO)$81In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "PF-06726304"

Select Batch
Purity:98.3%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).
Targets&IC50
EZH2 (Y641N):3.0 nM (ki), EZH2 (WT):0.7 nM (ki)
In vitro
PF-06726304 suppresses the proliferation of Karpas-422 cells that harbor wild-type EZH2 (IC50: 25 nM). PF-06726304 suppresses H3K27me3 in Karpas-422 (IC50: 15 nM) [1].
In vivo
In a subcutaneous Karpas-422 xenograft model, PF-06726304 (200 and 300 mg/kg; BID for 20 days) suppresses tumor growth and causes robust modulation of downstream biomarkers[1].
Chemical Properties
Molecular Weight446.33
FormulaC22H21Cl2N3O3
Cas No.1616287-82-1
SmilesCc1noc(C)c1-c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Relative Density.1.333 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (100.82 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2405 mL11.2025 mL22.4049 mL112.0247 mL
5 mM0.4481 mL2.2405 mL4.4810 mL22.4049 mL
10 mM0.2240 mL1.1202 mL2.2405 mL11.2025 mL
20 mM0.1120 mL0.5601 mL1.1202 mL5.6012 mL
50 mM0.0448 mL0.2240 mL0.4481 mL2.2405 mL
100 mM0.0224 mL0.1120 mL0.2240 mL1.1202 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy PF-06726304 | purchase PF-06726304 | PF-06726304 cost | order PF-06726304 | PF-06726304 chemical structure | PF-06726304 in vivo | PF-06726304 in vitro | PF-06726304 formula | PF-06726304 molecular weight