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PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | 32 € | In Stock | |
1 mL x 10 mM (in DMSO) | 51 € | In Stock |
Description | PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death. |
Targets&IC50 | RH4:812 nM, OSA-CL cells:1895nM, RH30:3200nM, TC-32 cells:1113nM |
In vitro | PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. |
Molecular Weight | 214.22 |
Formula | C11H10N4O |
Cas No. | 53995-62-3 |
Smiles | O=C(NNc1ccccn1)c1ccccn1 |
Relative Density. | 1.309 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 20 mg/mL (93.36 mM), Sonication and heating are recommended. DMSO: 40 mg/mL (186.72 mM) H2O: insoluble | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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