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Phaclofen
🥰Excellent
Catalog No. T23147Cas No. 114012-12-3
Alias 3-Amino-2-(4-chlorophenyl)propanephosphonic acid
Phaclofen (3-Amino-2-(4-chlorophenyl)propanephosphonic acid) is a selective GABAB receptor antagonist, which can partially antagonize the sedative effect of (-)-baclofen, and reversibly antagonize the inhibition of cholinergic convulsive response of guinea pig ileum and distal colon by baclofen or GABA. Inhibits the cholinergic convulsive response in the guinea pig ileum and distal colon by baclofen or GABA.
Phaclofen
🥰Excellent
Purity: 99.32%
Catalog No. T23147Alias 3-Amino-2-(4-chlorophenyl)propanephosphonic acidCas No. 114012-12-3
Phaclofen (3-Amino-2-(4-chlorophenyl)propanephosphonic acid) is a selective GABAB receptor antagonist, which can partially antagonize the sedative effect of (-)-baclofen, and reversibly antagonize the inhibition of cholinergic convulsive response of guinea pig ileum and distal colon by baclofen or GABA. Inhibits the cholinergic convulsive response in the guinea pig ileum and distal colon by baclofen or GABA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $74 | In Stock | |
| 5 mg | $179 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $687 | In Stock | |
| 50 mg | $955 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 200 mg | $1,730 | In Stock |
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Purity:99.32%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Phaclofen (3-Amino-2-(4-chlorophenyl)propanephosphonic acid) is a selective GABAB receptor antagonist, which can partially antagonize the sedative effect of (-)-baclofen, and reversibly antagonize the inhibition of cholinergic convulsive response of guinea pig ileum and distal colon by baclofen or GABA. Inhibits the cholinergic convulsive response in the guinea pig ileum and distal colon by baclofen or GABA. |
| In vivo | In Sprague-Dawley rats (180-250 g), Phaclofen (2 mg/kg; intraperitoneal injection) reduced the number of neuropeptide Y-like immunoreactive fibers in the stimulated cuneate nucleus[4]. |
| Alias | 3-Amino-2-(4-chlorophenyl)propanephosphonic acid |
| Molecular Weight | 249.63 |
| Formula | C9H13ClNO3P |
| Cas No. | 114012-12-3 |
| Smiles | O=P(O)(O)CC(C1=CC=C(Cl)C=C1)CN |
| Relative Density. | 1.432 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | 1eq. NaOH: <6.24 mg/mL H2O: 30 mg/mL (120.18 mM), Sonication and adjust pH with 1M OH DMSO: < 1 mg/mL (23.90 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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