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PKCε Inhibitor Peptide acetate

Catalog No. T35827L

Synonyms: PKCε Inhibitor Peptide acetate(182683-50-7 Free base)

PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-, and δPKC.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PKCε Inhibitor Peptide acetate Chemical Structure

PKCε Inhibitor Peptide acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
2 mg	In stock	$ 143.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 327.00
25 mg	In stock	$ 552.00
50 mg	In stock	$ 793.00
100 mg	In stock	$ 1,090.00

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Purity: 98.93%

Biological Description

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Description	PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-, and δPKC.
In vitro	PKCε Inhibitor Peptide acetate(1 µM; 24 hours) significantly inhibits Oleic acid-induced connexin 43 Ser368 phosphorylation and prevents Oleic acid-induced gap junction disassembly in cardiomyocytes[1].
In vivo	In C57BL/6J mice transplanted the hearts of FVB mice, PKCε Inhibitor Peptide acetate (20 mg/kg/day; osmotic pumps s.c.) significantly improved the beating score throughout the treatment. PKCε Inhibitor Peptide acetate treatment almost abolished the rise in pro-fibrotic cytokine, TGF-β, and monocyte recruiting chemokine MCP-1 levels. PKCε Inhibitor Peptide acetate reduced the infiltration of macrophages and T cells into the cardiac grafts and decreased parenchymal fibrosis[2].

Synonyms	PKCε Inhibitor Peptide acetate(182683-50-7 Free base)
Molecular Weight	904.02
Formula	C39H69N9O15

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yuahn-Sieh Huang, et al. Mechanism of oleic acid-induced gap junctional disassembly in rat cardiomyocytes. J Mol Cell Cardiol. 2004 Sep;37(3):755-66. 2. Tomoyoshi Koyanagi, et al. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 2007 Oct;43(4):517-22. 3. M Yedovitzky, et al. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J Biol Chem. 1997 Jan 17;272(3):1417-20.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library TGF-beta/Smad Compound Library Peptide Compound Library Epigenetics Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

A-3 hydrochloride CP21R7 Darovasertib Ellagic acid HIV-1 protease-IN-10 Afuresertib PKCα (C2-4) inhibitor peptide K-252c

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PKCε Inhibitor Peptide acetate Chromatin/Epigenetic Cytoskeletal Signaling PKC PKCε Inhibitor Peptide Acetate PKCε Inhibitor Peptide acetate(182683-50-7 Free base) inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.