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Podocarpusflavone A
🥰Excellent
Catalog No. TQ0134Cas No. 22136-74-9
Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7.
Podocarpusflavone A
🥰Excellent
Purity: 99.26%
Catalog No. TQ0134Cas No. 22136-74-9
Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $81 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $297 | In Stock |
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Purity:99.26%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7. |
| Targets&IC50 | Topo I:119.425 μM (IC50), FASN:24.08 |
| In vitro | Podocarpusflavone A showed significant inhibition against KB, DLD, HEp-2, MCF-7 tumour cell lines (ED50 4.56-16.24 μg/mL). It induced cell apoptosis in MCF-7 mainly via sub-G1/S phase arrest. PF (40 ug/mL, 24 hours) induced a significant increase in cell death and growth arrest in the S phase by about 10-fold compared to the control group;[1]Podocarpusflavone A (0,5,10,20 μM) treatment of four melanoma cell lines (A375, Malme-3M, SK-MEL-1, and SK-MEL5) for 24 h significantly inhibited p-STAT3 levels, but not total STAT3 protein levels, in all cell lines tested. In addition, a dose-dependent inhibition of p-STAT3 expression was observed in both A375 and SK-MEL-1 cells and the IC50 values were approximately 10 μM for both A375 and SK-MEL-1 cells.[2] |
| In vivo | Podocarpusflavone A was administered daily to A375 cell-derived xenograft mice (20, 40 mg/kg, po, for 21 days), and Podocarpusflavone A significantly suppressed tumor size and weight in xenograft mice. [2] |
| Molecular Weight | 552.48 |
| Formula | C31H20O10 |
| Cas No. | 22136-74-9 |
| Smiles | COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(=O)c4c(O)cc(O)cc4o3)c2o1 |
| Relative Density. | 1.576 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (72.40 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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