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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $147 | In Stock | |
5 mg | $378 | In Stock | |
10 mg | $558 | In Stock | |
25 mg | $886 | In Stock | |
50 mg | $1,190 | In Stock | |
100 mg | $1,580 | In Stock | |
1 mL x 10 mM (in DMSO) | $429 | In Stock |
Description | Polyporenic acid C shows inhibitory activity against human collagenase. |
In vitro | Polyporenic acid C (PPAC) significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan-caspase inhibitors but not by a caspase-9 inhibitor. |
Molecular Weight | 482.69 |
Formula | C31H46O4 |
Cas No. | 465-18-9 |
Storage | keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (124.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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