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Pomolic acid

Pomolic acid
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Purity:96.84%
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Pomolic acid

Catalog No. TN2097Cas No. 13849-91-7
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.
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Pack SizePriceAvailabilityQuantity
1 mg$152In Stock
5 mg$373In Stock
10 mg$556In Stock
25 mg$896In Stock
50 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$420In Stock
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Product Introduction

Bioactivity
Description
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.
In vitro
Oleanolic acid (1) was identified as an anti-HIV principle from several plants, including Rosa woodsii (leaves), Prosopis glandulosa (leaves and twigs), Phoradendron juniperinum (whole plant), Syzygium claviflorum (leaves), Hyptis capitata (whole plant), and Ternstromia gymnanthera (aerial part). It inhibited HIV-1 replication in acutely infected H9 cells with an EC50 value of 1.7 microg/mL, and inhibited H9 cell growth with an IC50 value of 21.8 microg/mL [therapeutic index (T. I.) 12.8]. Pomolic acid, isolated from R. woodsii and H. capitata, was also identified as an anti-HIV agent (EC50 1.4 microg/mL, T. I. 16.6). Although ursolic acid did show anti-HIV activity (EC50 2.0 microg/mL), it was slightly toxic (IC50 6.5 microg/mL, T. I. 3.3). A new triterpene (11) was also isolated from the CHCl3-soluble fraction of R. woodsii, though it showed no anti-HIV activity. The structure of 11 was determined to be 1beta-hydroxy-2-oxoPomolic acid by spectral examination. Based on these results, we examined the anti-HIV activity of oleanolic acid- or Pomolic acid-related triterpenes isolated from several plants. In addition, we previously demonstrated that derivatives of betulinic acid, isolated from the leaves of S. claviflorum as an anti-HIV principle, exhibited extremely potent anti-HIV activity[1]
Chemical Properties
Molecular Weight472.7
FormulaC30H48O4
Cas No.13849-91-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 60 mg/ml (126.93 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1155 mL10.5775 mL21.1551 mL105.7753 mL
5 mM0.4231 mL2.1155 mL4.2310 mL21.1551 mL
10 mM0.2116 mL1.0578 mL2.1155 mL10.5775 mL
20 mM0.1058 mL0.5289 mL1.0578 mL5.2888 mL
50 mM0.0423 mL0.2116 mL0.4231 mL2.1155 mL
100 mM0.0212 mL0.1058 mL0.2116 mL1.0578 mL

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