pentacyclic triterpene

Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.

Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.

Tingenone is a pentacyclic triterpene. It induces peripheral antinociception due to opioidergic activation.

Madecassoside (Asiaticoside A) is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.

Isoasiaticoside, a pentacyclic triterpene saponin derived from Centella asiatica, exhibits potential neuroprotective effects in the 6-OHDA-induced PC12 cell model [1].

Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.

Arnidiol, a pentacyclic triterpene isolated from Barleria Longiflora Linn, exhibits anti-inflammatory activity, notably inhibiting 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.

Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.

Centellasaponin A (compound 10), a pentacyclic triterpene saponin, has been isolated from the methanolic extract of Centella asiatica [1].