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Pz-1
🥰Excellent
Catalog No. T12598Cas No. 1800505-64-9
Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.
Pz-1
🥰Excellent
Purity: 99.95%
Catalog No. T12598Cas No. 1800505-64-9
Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $85 | In Stock | |
| 25 mg | $172 | In Stock | |
| 50 mg | $278 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $53 | In Stock |
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Purity:99.95%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth. |
| Targets&IC50 | RET/VEGFR2:< 1 nM |
| In vitro | Pz-1(1.0 nM) strongly inhibited phosphorylation of all tested RET oncoproteins in cell-based assays with IC50s of less than 1 nM for both VEGFR2 and RET wild type kinases[1]. |
| In vivo | Pz-1 (1.0 mg/kg) abrogated the formation of tumors induced by RET-mutant fibroblasts and blocked the phosphorylation of both RET and VEGFR2 in tumor tissue. Pz-1 featured no detectable toxicity at concentrations of up to 100.0 mg/kg[1]. |
| Molecular Weight | 454.52 |
| Formula | C26H26N6O2 |
| Cas No. | 1800505-64-9 |
| Smiles | Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1 |
| Relative Density. | 1.28 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (99.01 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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