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QX-314 chloride

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Purity:99.84%

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COA HNMR LCMS

QX-314 chloride

Catalog No. T12608Cas No. 5369-03-9

QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.

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Pack Size	Price	Availability
25 mg	$48	In Stock
50 mg	$82	In Stock
100 mg	$132	In Stock

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Product Introduction

Bioactivity

Description

QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.

In vitro

QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].

Chemical Properties

Molecular Weight	298.85
Formula	C16H27ClN2O
Cas No.	5369-03-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14.29 mg/mL (47.82 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3462 mL	16.7308 mL	33.4616 mL	167.3080 mL
5 mM	0.6692 mL	3.3462 mL	6.6923 mL	33.4616 mL
10 mM	0.3346 mL	1.6731 mL	3.3462 mL	16.7308 mL
20 mM	0.1673 mL	0.8365 mL	1.6731 mL	8.3654 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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