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RBN-2397

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Purity:99.96%

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COA HNMR HPLC

RBN-2397

Catalog No. T12695Cas No. 2381037-82-5

RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.

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Pack Size	Price	Availability
1 mg	$132	In Stock
5 mg	$328	In Stock
10 mg	$496	In Stock
25 mg	$793	In Stock
50 mg	$1,070	In Stock
100 mg	$1,380	In Stock
1 mL x 10 mM (in DMSO)	$457	In Stock

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Product Introduction

Bioactivity

Description	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.
Targets&IC50	PARP7:3 nM (IC50), PARP7:1 nM (Kd)
In vitro	Inhibition of PARP7 with RBN-2397 can potently inhibit the growth of cancer cells and restore interferon signaling, effectively releasing the brake cancer uses to hide from the immune system and suppress both innate and adaptive immune mechanisms.RBN-2397 inhibits cells proliferation(IC50 value of 20 nM in NCI-H1373 lung cancer cells), shows a restoration of type I IFN response by an increase in STAT1 phosphorylation as a dose-dependent manner in NCI-H1373 human lung cancer cells,and inhibits cell MARylation in a cell biochemial assay with an EC50 value of 1 nM[2].
In vivo	RBN-2397 oral administration induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses in CT26 tumor-bearing BALB/c mice.RBN-2397 oral administration causes complete regressions at the dose 100 mg/kg and exerts a dose-dependent effects on tumor growth at dose levels of ≥30 mg/kg.The half-life (t1/2) of RBN-2397 in vivo is 325 mins[2].

Chemical Properties

Molecular Weight	523.43
Formula	C20H23F6N7O3
Cas No.	2381037-82-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 247 mg/mL (471.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9105 mL	9.5524 mL	19.1048 mL	95.5238 mL
5 mM	0.3821 mL	1.9105 mL	3.8210 mL	19.1048 mL
10 mM	0.1910 mL	0.9552 mL	1.9105 mL	9.5524 mL
20 mM	0.0955 mL	0.4776 mL	0.9552 mL	4.7762 mL
50 mM	0.0382 mL	0.1910 mL	0.3821 mL	1.9105 mL
100 mM	0.0191 mL	0.0955 mL	0.1910 mL	0.9552 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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