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Rupintrivir

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Purity:99.35%

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COA HPLC MS HNMR

Rupintrivir

Catalog No. T16809Cas No. 223537-30-2

Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.

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Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$287	In Stock
10 mg	$455	In Stock
25 mg	$747	In Stock
50 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$369	In Stock

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Product Introduction

Bioactivity

Description	Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.
In vitro	In H1-HeLa and MRC-5 cell protection assays, Rupintrivir (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 microM (range, 0.003 to 0.081 microM) and a mean EC90 of 0.082 microM (range, 0.018 to 0.261 microM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1].
In vivo	PCLS from HDM-sensitized mice showed an attenuated antiviral response, but exaggerated IL-4, IL-6, and IL-10 secretion upon infection. Rupintrivir(AG7088) inhibited exaggerated pro-inflammatory cytokine IL-6 and TH-2 cytokine IL-4 in HDM-sensitized mice[2].
Alias	AG-7088, AG7088, Rupintrivirvr

Chemical Properties

Molecular Weight	598.66
Formula	C31H39FN4O7
Cas No.	223537-30-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (50.11 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6704 mL	8.3520 mL	16.7040 mL	83.5199 mL
5 mM	0.3341 mL	1.6704 mL	3.3408 mL	16.7040 mL
10 mM	0.1670 mL	0.8352 mL	1.6704 mL	8.3520 mL
20 mM	0.0835 mL	0.4176 mL	0.8352 mL	4.1760 mL
50 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6704 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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