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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $191 | In Stock | |
5 mg | $480 | In Stock | |
10 mg | $687 | In Stock | |
25 mg | $1,080 | In Stock | |
50 mg | $1,480 | In Stock |
Description | Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity. |
In vitro | Ruzasvir (MK-8408) was developed as a novel NS5A inhibitor to improve upon the potency and barrier to resistance of early compounds. Ruzasvir inhibited HCV RNA replication with 50% effective concentrations (EC50s) of 1 to 4 pM in Huh7 or Huh7.5 cells bearing replicons for HCV genotype 1 (GT1) to GT7. The antiviral activity was modestly (10-fold) reduced in the presence of 40% normal human serum. The interaction of Ruzasvir with an NS3/4A protease inhibitor (grazoprevir) and an NS5B polymerase prodrug (uprifosbuvir) was additive to synergistic, with no evidence of antagonism or cytotoxicity.[1] |
Alias | MK8408, MK-8408, MK 8408 |
Molecular Weight | 947.09 |
Formula | C49H55FN10O7S |
Cas No. | 1613081-64-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (52.79 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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