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SEP-363856 mesylate
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Catalog No. T201258Cas No. 2375116-27-9
Alias SEP-856 mesylate
SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.
SEP-363856 mesylate
😃Good
Catalog No. T201258Alias SEP-856 mesylateCas No. 2375116-27-9
SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia. |
| Targets&IC50 | 5-HT1D Receptor:0.262 μM (EC50), 5-HT2A Receptor:>10 μM (EC50), 5-HT1A Receptor:2.3 μM (EC50, TAAR1:0.14 μM (EC50), 5-HT7 Receptor:6.7 μM (EC50), 5-HT1B Receptor:15.6 μM (EC50), 5-HT2C Receptor:30 μM (EC50) |
| In vitro | SEP-856 mesylate (10 μM) demonstrates greater than 50% inhibition of specific binding at several receptors, including α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7. |
| In vivo | SEP-856 mesylate, administered intraperitoneally (0.3, 1, and 10 mg/kg), demonstrates CNS activity and a behavioral profile akin to established antipsychotic medications. When given orally (0.3, 1, and 10 mg/kg, once), SEP-856 mesylate notably diminishes PCP-induced hyperactivity. Additionally, oral dosage of SEP-856 mesylate (1, 3, and 10 mg/kg) leads to a dose-dependent reduction in REM sleep, prolongation in the latency period to REM sleep, and an extension in cumulative wake (W) time. |
| Alias | SEP-856 mesylate |
| Molecular Weight | 279.38 |
| Formula | C10H17NO4S2 |
| Cas No. | 2375116-27-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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