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SEP-363856 hydrochloride

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Purity:99.99%

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COA HPLC HNMR

SEP-363856 hydrochloride

Catalog No. T12899LCas No. 1310422-41-3

SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia.

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Pack Size	Price	Availability
1 mg	$64	In Stock
2 mg	$93	In Stock
5 mg	$156	In Stock
10 mg	$255	In Stock
25 mg	$448	In Stock
50 mg	$662	In Stock
100 mg	$987	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock

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Product Introduction

Bioactivity

Description	SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia.
In vitro	SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.
In vivo	SEP-856 (0.3, 1 and 10 mg/kg, i.p.) is CNS active. SEP-856 exhibits a behavioral signature similar to known antipsychotic drugs.PCP-induced hyperactivitysignificantly reduced by SEP-856 (0.3, 1 and 10 mg/kg, orally once) . Oral SEP-856 administration (1, 3 and 10 mg/kg) produces a dosedependent decrease in REM sleep, increase in latency to REM sleep and increase in cumulative wake (W) time.
Alias	SEP-856 hydrochloride

Chemical Properties

Molecular Weight	219.73
Formula	C9H14ClNOS
Cas No.	1310422-41-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (250.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5510 mL	22.7552 mL	45.5104 mL	227.5520 mL
5 mM	0.9102 mL	4.5510 mL	9.1021 mL	45.5104 mL
10 mM	0.4551 mL	2.2755 mL	4.5510 mL	22.7552 mL
20 mM	0.2276 mL	1.1378 mL	2.2755 mL	11.3776 mL
50 mM	0.0910 mL	0.4551 mL	0.9102 mL	4.5510 mL
100 mM	0.0455 mL	0.2276 mL	0.4551 mL	2.2755 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify

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