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SR33805

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Purity:98.94%

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COA HPLC HNMR

SR33805

Catalog No. T8674Cas No. 121345-64-0

SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)

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Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$147	In Stock
10 mg	$247	In Stock
25 mg	$446	In Stock
50 mg	$659	In Stock
100 mg	$938	In Stock
1 mL x 10 mM (in DMSO)	$183	In Stock

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Product Introduction

Bioactivity

Description	SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
Targets&IC50	Ca2+ channel, L-type:4.1 nM (EC50, in depolarized conditions), Ca2+ channel, L-type:33 nM (EC50, in polarized conditions)
In vitro	Acute treatment with SR33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes.?Indeed, a SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation.?Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR33805.?Finally, administration of a single intra-peritoneal bolus of SR33805 (20 mg/kg) improved end-systolic strain and fractional shortening of MI hearts[1]

Chemical Properties

Molecular Weight	564.74
Formula	C32H40N2O5S
Cas No.	121345-64-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 27.5 mg/mL (48.69 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7707 mL	8.8536 mL	17.7073 mL	88.5363 mL
5 mM	0.3541 mL	1.7707 mL	3.5415 mL	17.7073 mL
10 mM	0.1771 mL	0.8854 mL	1.7707 mL	8.8536 mL
20 mM	0.0885 mL	0.4427 mL	0.8854 mL	4.4268 mL

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