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SRS11-92

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Purity:98.67%

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COA HPLC HNMR

SRS11-92

Catalog No. T8922Cas No. 1467047-25-1

SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1

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Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$73	In Stock
10 mg	$118	In Stock
25 mg	$239	In Stock
50 mg	$378	In Stock
100 mg	$579	In Stock
500 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Product Introduction

Bioactivity

Description	SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1
In vitro	SRS11-92 inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM).?SRS11-92 (2 M) inhibits iron-induced cell death in isolated mouse kidney proximal tubules, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM.
In vivo	SRS11-92 increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington s disease in a concentration-dependent manner.?SRS11-92 (3 M) increases production of reactive oxygen species (ROS) in L. major promastigotes in a time-dependent manner.?It is selectively toxic to L. major promastigotes (LD50 = 3.34 M) over U2OS human osteoblasts, RAW 264.7 macrophages, and intraperitoneal macrophages when used at a concentration of 80 M.
Alias	AA9

Chemical Properties

Molecular Weight	352.47
Formula	C22H28N2O2
Cas No.	1467047-25-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (28.37 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8371 mL	14.1856 mL	28.3712 mL	141.8560 mL
5 mM	0.5674 mL	2.8371 mL	5.6742 mL	28.3712 mL
10 mM	0.2837 mL	1.4186 mL	2.8371 mL	14.1856 mL
20 mM	0.1419 mL	0.7093 mL	1.4186 mL	7.0928 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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