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SRS11-92
Catalog No. T8922Cas No. 1467047-25-1
Alias AA9
SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1
SRS11-92
Catalog No. T8922Alias AA9Cas No. 1467047-25-1
SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $38 | In Stock | |
| 5 mg | $73 | In Stock | |
| 10 mg | $118 | In Stock | |
| 25 mg | $239 | In Stock | |
| 50 mg | $378 | In Stock | |
| 100 mg | $579 | In Stock | |
| 500 mg | $1,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $107 | In Stock |
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Purity:98.67%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1 |
| In vitro | SRS11-92 inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM).?SRS11-92 (2 M) inhibits iron-induced cell death in isolated mouse kidney proximal tubules, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM. |
| In vivo | SRS11-92 increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington s disease in a concentration-dependent manner.?SRS11-92 (3 M) increases production of reactive oxygen species (ROS) in L. major promastigotes in a time-dependent manner.?It is selectively toxic to L. major promastigotes (LD50 = 3.34 M) over U2OS human osteoblasts, RAW 264.7 macrophages, and intraperitoneal macrophages when used at a concentration of 80 M. |
| Alias | AA9 |
| Molecular Weight | 352.47 |
| Formula | C22H28N2O2 |
| Cas No. | 1467047-25-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (28.37 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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