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Tapinarof

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Purity:99.84%

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COA HPLC HNMR

Tapinarof

Catalog No. T4644Cas No. 79338-84-4

Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$77	In Stock
10 mg	$126	In Stock
25 mg	$243	In Stock
50 mg	$369	In Stock
100 mg	$549	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Product Introduction

Bioactivity

Description	Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
In vitro	Tapinarof activates the AhR pathway through direct binding. Tapinarof induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) in a dose-dependent way.
In vivo	Tapinarof mediates its anti-inflammatory effects via the AhR pathway in IMQ-treated mice. In mice expressing AhR on a C57Bl/6 background, both Tapinarof and 6-formylindolo(3,2-b)carbazole (FICZ) significantly lower clinical inflammation scores. Conversely, AhR knockout (KO) mice exhibit no such anti-inflammatory response to Tapinarof. FICZ serves as a benchmark in these experiments, demonstrating comparable reduction in inflammation in wild-type mice, but ineffective in AhR KO mice.
Alias	GSK2894512, Benvitimod, WBI 1001

Chemical Properties

Molecular Weight	254.32
Formula	C17H18O2
Cas No.	79338-84-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (216.26 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9321 mL	19.6603 mL	39.3205 mL	196.6027 mL
5 mM	0.7864 mL	3.9321 mL	7.8641 mL	39.3205 mL
10 mM	0.3932 mL	1.9660 mL	3.9321 mL	19.6603 mL
20 mM	0.1966 mL	0.9830 mL	1.9660 mL	9.8301 mL
50 mM	0.0786 mL	0.3932 mL	0.7864 mL	3.9321 mL
100 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9660 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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