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TAS0728
🥰Excellent
Catalog No. T7819Cas No. 2088323-16-2
TAS0728 is a HER2 inhibitor, with antitumor activity
TAS0728
🥰Excellent
Purity: 97.78%
Catalog No. T7819Cas No. 2088323-16-2
TAS0728 is a HER2 inhibitor, with antitumor activity
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $43 | In Stock | |
| 5 mg | $113 | In Stock | |
| 10 mg | $178 | In Stock | |
| 25 mg | $338 | In Stock | |
| 50 mg | $538 | In Stock | |
| 100 mg | $732 | In Stock | |
| 200 mg | $986 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $119 | In Stock |
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Purity:97.78%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TAS0728 is a HER2 inhibitor, with antitumor activity |
| Targets&IC50 | BMX:4.9 nM , HER4:8.5 nM , HER2 (human):36 nM , BLK:31 nM , HER2:13 nM , JAK3:33 nM, EGFR:65 nM |
| In vitro | TAS0728 exhibited robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors, thereby inducing apoptosis of HER2-amplified breast cancer cells and in tumor tissues of a xenograft model.?TAS0728 induced tumor regression in mouse xenograft models bearing HER2 signal-dependent tumors and exhibited a survival benefit without any evident toxicity in a peritoneal dissemination mouse model bearing HER2-driven cancer cells[1]. |
| Molecular Weight | 504.58 |
| Formula | C26H32N8O3 |
| Cas No. | 2088323-16-2 |
| Smiles | CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C |
| Relative Density. | 1.35 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (247.73 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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