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TGR5 Receptor Agonist

TGR5  Receptor Agonist
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Purity:99.77%
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TGR5 Receptor Agonist

Catalog No. T1824Cas No. 1197300-24-5
TGR5 is a potent TGR5(GPCR19) agonist.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
5 mg$79In Stock
10 mg$133In Stock
25 mg$263In Stock
50 mg$483In Stock
100 mg$693In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Related Compound Libraries of "TGR5 Receptor Agonist"

Product Introduction

Bioactivity
Description
TGR5 is a potent TGR5(GPCR19) agonist.
Kinase Assay
Inhibition assays are carried out in 384-well white ProxiPlates in 10 μL of reaction volume. Standard reaction mixtures consisted of the compound (in 2% DMSO final concentration), enzyme mix (0.001 μM of PHD2, 10 μM of Fe(II), 100 μM of ascorbate) and peptide mix (0.06 μM of biotinylated C-terminal oxygen dependent degradation domain (CODD) peptide, 2 μM of 2OG) in 50 mM HEPES pH 7.5, 0.01% Tween-20 and 0.1% BSA buffer. Compounds (e.g., IOX2) are preincubated with the enzyme mix for 15 min before being incubated with peptide mix for 10 min at 22°C. Each reaction is quenched with 5 μL of 30 mM EDTA. The bead mix containing AlphaScreen beads is preincubated for 1h with a rabbit monoclonal antibody selective for hydroxy-HIF1α (Pro564) and are added to the wells for a further 1 h at 22°C. The plates are then analyzed with an Envision plate reader. The IC50 values are calculated using nonlinear regression with normalized dose-response fit using Prism GraphPad (n≥3)[1].
Chemical Properties
Molecular Weight361.22
FormulaC18H14Cl2N2O2
Cas No.1197300-24-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (138.42 mM)
Ethanol: 100 mM
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.7684 mL13.8420 mL27.6840 mL138.4198 mL
5 mM0.5537 mL2.7684 mL5.5368 mL27.6840 mL
10 mM0.2768 mL1.3842 mL2.7684 mL13.8420 mL
20 mM0.1384 mL0.6921 mL1.3842 mL6.9210 mL
50 mM0.0554 mL0.2768 mL0.5537 mL2.7684 mL
100 mM0.0277 mL0.1384 mL0.2768 mL1.3842 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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